Lemsalu uses porcelain, fur, wool, textile, plastic, silicone, ready-mades as the material of her work. Lemsalu’s work displays attention to color, and effects of the surface, an interest in archetypical and symbolic motives, and also an ironic and reflexive relationship to her medium, with scenographic and absurd humor. Her art includes self-portraits and photo scenes in addition to her abstract sculptures. Her artistic message is focused on the individual and the existential reaction of the individual towards the world.

Aside from installations, musical performances also play an important part in Lemsalu’s oevre. For example, “Going Going” at the Performa biennial in New York (2017), “In Heaven Everything is Fine” in KOKO, London (2017), “The Birth of Venus” (2010) and collaboration with art group Gelitin. In public Lemsalu often appears costumized. The documentation of her installations and costumes are published in “Kris Lemsalu” (published by Temnikova & Kasela gallery, 2015) and "Kris Lemsalu. Birth V - Hi and Bye" (published by Estonian Centre for Contemporary Art, 2019).

Participating in the Biennale Arte 2019, Lemsalu characterized the city of Venice "as a living creature, perpetually decadent and yet endlessly revived." Unlike her earlier works in which Lemsalu focused on engaging death as the main topic, in her Venice Biennale show, she was "more concerned with life – although death wears a carnival mask in Venice anyway." During this time, Lemsalu worked along with group of people including "the curator Maria Arusoo, the poet Andrew Berardini, the mentor Sarah Lucas, the researcher Irene Campolmi, her friend/collaborator Tamara Luuk and performers who brought the inaugural ritual to life during the opening of the Biennale."